The Relationship between Tuberculosis and Corona Virus

Authors

  • Saja A. Shareef Assistant lecturer, Molecular and Medical Biotechnology Department, College of Biotechnology, Al-Nahrain University, Baghdad, IRAQ.
  • Mays K. Aldulaimy Assistant lecturer, Plant Biotechnology Department, College of Biotechnology Al-Nahrain University, Baghdad, IRAQ.
  • Walaa A. Mohammed Assistant lecturer, Microbiology department, College of science, AL-Karkh University of science, Baghdad, IRAQ.

DOI:

https://doi.org/10.55544/sjmars.3.5.4

Keywords:

RT-PCR, COVID-19, Tuberculosis, corona virus

Abstract

In 2020, COVID-19 and tuberculosis emerged as significant threats to global health, with increased mortality and decreased testing due to the pandemic's impact on the tuberculosis care system. Both diseases spread through respiratory system secretions and airborne particles, with the lungs being their primary target organ. Common remedies include addressing the spread of Mycobacterium tuberculosis and addressing the underlying causes of both diseases. COVID-19 diagnostics include quick antigen test kits and RT-PCR, while tuberculosis diagnostics include chest X-rays, sputum microscopy, and RT-PCR on sputum. These methods allow for same-day active TB diagnosis, compared to culture-based testing that could take up to eight weeks. Using a range of diagnostic tools ensures that COVID-19 and TB patients are identified and treated promptly. The combined danger of TB and COVID-19 presents a significant challenge to patient quality of life. To effectively combat this combined threat, cooperation, research funding, and policy changes are necessary.

References

Andom AT, Fejfar D, Yuen CM, Ndayizigiye M, Mugunga JC, Mukherjee JS. The impact of COVID-19 on tuberculosis program performance in the Kingdom of Lesotho. Trop Med Infect Dis. 2023;8(3):165. pmid:36977166

Berra TZ, Ramos ACV, Alves YM, Tavares RBV, Tartaro AF, Nascimento MCD, et al. Impact of COVID-19 on tuberculosis indicators in Brazil: a time series and spatial analysis study. Trop Med Infect Dis. 2022;7(9):247. pmid:36136658

Chiang CY, Islam T, Xu C, Chinnayah T, Garfin AMC, Rahevar K, et al. The impact of COVID-19 and the restoration of tuberculosis services in the Western Pacific Region. Eur Respir J. 2020;56(4):2003054. pmid:32978310

Dlangalala T, Musekiwa A, Brits A, Maluleke K, Jaya ZN, Kgarosi K, et al. Evidence of TB services at primary healthcare level during COVID-19: a scoping review. Diagnostics (Basel). 2021;11(12):2221. pmid:34943458

Fuady A, Houweling TAJ, Richardus JH. COVID-19 and Tuberculosis-Related Catastrophic Costs. Am J Trop Med Hyg. 2020;104(2):436–40. pmid:33269683

Khan AW, Khan B, Shah SK, Kazi GN, Quadir A, Ghafoor A, et al. The impact of covid-19 on TB care in Pakistan during 2020. Pak J Public Health. 2022;12(1):8–11.

Khobragade RN, Kelkar RU, Sunilkumar M, Cency B, Murthy N, Surendran D, et al. Health system resilience: ensuring TB services during COVID-19 pandemic in Kerala, India. Indian J Tuberc. 2022;69(4):427–31. pmid:36460371

Kim B, Kang YA, Lee J. Heterogeneous impact of Covid-19 response on tuberculosis burden by age group. Sci Rep. 2022;12(1):13773. pmid:35962020

Klinton JS, Oga-Omenka C, Heitkamp P. TB and COVID—Public and private health sectors adapt to a new reality. J Clin Tuberc Other Mycobact Dis. 2020;21:100199. pmid:33163631

Manhiça I, Augusto O, Sherr K, Cowan J, Cuco RM, Agostinho S, et al. COVID-19-related healthcare impacts: an uncontrolled, segmented time-series analysis of tuberculosis diagnosis services in Mozambique, 2017–2020. BMJ Glob Health. 2022;7(4):e007878. pmid:35443938

Mihika FA, Jubayer Biswas MAA, Khan MMH, Islam SS, Haque MA, Banu S, et al. The effect of the COVID-19 pandemic on pulmonary tuberculosis control in the selected Upazila health complexes of Dhaka Division, Bangladesh. Trop Med Infect Dis. 2022;7(11):385. pmid:36422935

Min J, Kim HW, Koo HK, Ko Y, Oh JY, Kim J, et al. Impact of COVID-19 pandemic on the National PPM Tuberculosis Control Project in Korea: the Korean PPM Monitoring Database between July 2019 and June 2020. J Korean Med Sci. 2020;35(43):e388. pmid:33169559

Nhari LG, Dzobo M, Chitungo I, Denhere K, Musuka G, Dzinamarira T. Implementing effective TB prevention and treatment programmes in the COVID-19 era in Zimbabwe. A call for innovative differentiated service delivery models. Public Health Pract (Oxf). 2020;1:100058.

Oga-Omenka C, Sassi A, Vasquez NA, Baruwa E, Rosapep L, Daniels B, et al. Tuberculosis service disruptions and adaptations during the first year of the COVID-19 pandemic in the private health sector of two urban settings in Nigeria-A mixed methods study. PLOS Glob Public Health. 2023;3(3):e0001618. pmid:36963094

Petersen E, Seif Al-Abr S, Chakaya J, Goletti D, Parolina L, Wejse C, et al. World TB Day 2022: Revamping and reshaping global TB control programs by advancing lessons learnt from the COVID-19 pandemic. Int J Infect Dis. 2022;124(Suppl 1):S1–3. pmid:35248715

Reid MJA, Silva S, Arinaminpathy N, Goosby E. Building a tuberculosis-free world while responding to the COVID-19 pandemic. Lancet. 2020;396:1312–13. pmid:34338198

Tran CH, Moore BK, Pathmanathan I, Lungu P, Shah NS, Oboho I, et al. Tuberculosis treatment within differentiated service delivery models in global HIV/TB programming. J Int AIDS Soc. 2021;24(Suppl 6):e25809. pmid:34713974

van Rensburg AJ, Petersen I, Awotiwon A, Bachmann MO, Curran R, Murdoch J, et al. Applying learning health systems thinking in codeveloping integrated tuberculosis interventions in the contexts of COVID-19. BMJ Glob Health. 2022;7(10):e009567. pmid:36316026

Cronin AM, Railey S, Fortune D, Wegener DH, Davis JB. Notes from the field: effects of the COVID-19 response on tuberculosis prevention and control efforts—United States, March-April 2020. MMWR Morb Mortal Wkly Rep. 2020;69(29):971–2. pmid:32701944

Bouaddi O, Hasan MM, Sahito AM, Shah PA, Mohammed AZA, Essar MY. Tuberculosis in the middle of COVID-19 in Morocco: efforts, challenges and recommendations. Trop Med Health. 2021;49(1):98. pmid:34930506

Roberts T, Sahu S, Malar J, Abdullaev T, Vandevelde W, Pillay YG, et al. Turning threats into opportunities: how to implement and advance quality TB services for people with HIV during the COVID-19 pandemic and beyond. J Int AIDS Soc. 2021;24(4):e25696. pmid:33787058

Yadav P, Vohra C, Gopalakrishnan M, Garg MK. Integrating health planning and primary care infrastructure for COVID-19 and tuberculosis care in India: challenges and opportunities. Int J Health Plann Manage. 2022;37(2):632–42. pmid:34820907

Ruiz-Grosso P, Cachay R, De La Flor A, Schwalb A, Ugarte-Gil C. Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis. PLOS ONE. 2020;15(1):e0227472. pmid:31923280

Loveday M, Cox H, Evans D, Furin J, Ndjeka N, Osman M, et al. Opportunities from a new disease for an old threat: Extending COVID-19 efforts to address tuberculosis in South Africa. S Afr Med J. 2020;110(12):1160–7. pmid:33403958

Ferrer JP, Suzuki S, Alvarez C, Berido C, Caballero M, Caraig B, et al. Experiences, challenges and looking to the future in a clinical tuberculosis cohort in the time of COVID-19 in the Philippines. Trans R Soc Trop Med Hyg. 2021;115(6):579–82. pmid:33693916

Malik AA, Hussain H, Maniar R, Safdar N, Mohiuddin A, Riaz N, et al. Integrated tuberculosis and COVID-19 activities in Karachi and tuberculosis case notifications. Trop Med Infect Dis. 2022;7(1):12. pmid:35051128

Zimmer AJ, Heitkamp P, Malar J, Dantas C, O’Brien K, Pandita A, et al. Facility-based directly observed therapy (DOT) for tuberculosis during COVID-19: a community perspective. J Clin Tuberc Other Mycobact Dis. 2021;24:100248. pmid:34189276

Sunjaya DK, Paskaria C, Pramayanti M, Herawati DMD, Parwati I. The magnitude of anxiety and depressive symptoms among tuberculosis patients in community health centers setting during the peak of COVID-19 pandemic. J Multidiscip Healthc. 2022;15:755–64. pmid:35422627

ACTION Global Health Advocacy Partnership et al. The impact of COVID-19 on the TB epidemic: a community perspective, 2020. Available from: https://spark.adobe.com/page/xJ7pygvhrIAqW/

Mandal A, Verma AK, Kar SK, Bajpai J, Kant S, Kumar S, et al. A cross-sectional study to determine the psychological distress among pulmonary tuberculosis patients during COVID-19 pandemic. Monaldi Arch Chest Dis. 2022;93(1) pmid:35593023

Millones AK, Lecca L, Acosta D, Campos H, Del Águila-Rojas E, Farroñay S, et al. The impact of the COVID-19 pandemic on patients’ experiences obtaining a tuberculosis diagnosis in Peru: a mixed-methods study. BMC Infect Dis. 2022;22(1):829. pmid:36352374

Santos FLD, Souza LLL, Bruce ATI, Crispim JA, Arroyo LH, Ramos ACV, et al. Patients’ perceptions regarding multidrug-resistant tuberculosis and barriers to seeking care in a priority city in Brazil during COVID-19 pandemic: A qualitative study. PLoS One. 2021;16(4):e0249822. pmid:33836024

Tinoco EM, Vasconcelos A, Alves F, Duarte R. Impact of COVID-19 on extrapulmonary TB and the benefit of decentralised TB services. Int J Tuberc Lung Dis. 2022;26(2):178–80. pmid:35086634

Togun T, Kampmann B, Stoker NG, Lipman M. Anticipating the impact of the COVID-19 pandemic on TB patients and TB control programmes. Ann Clin Microbiol Antimicrob. 2020;19(1):21. pmid:32446305

Zhang G, Yu Y, Zhang W, Shang J, Chen S, Pang X, et al. Influence of COVID-19 for delaying the diagnosis and treatment of pulmonary tuberculosis-Tianjin, China. Front Public Health. 2022;10:937844. pmid:36530737

Mwamba C, Kerkhoff AD, Kagujje M, Lungu P, Muyoyeta M, Sharma A. Diagnosed with TB in the era of COVID-19: patient perspectives in Zambia. Public Health Action. 2020;10(4):141–6. pmid:33437679

Beyene NW, Sitotaw AL, Tegegn B, Bobosha K. The impact of COVID-19 on the tuberculosis control activities in Addis Ababa. Pan Afr Med J. 2021;38:243. pmid:34104291

Buonsenso D, Iodice F, Sorba Biala J, Goletti D. COVID-19 effects on tuberculosis care in Sierra Leone. Pulmonology. 2021;27(1):67–9. pmid:32561353

Fatima R, Akhtar N, Yaqoob A, Harries AD, Khan MS. Building better tuberculosis control systems in a post-COVID world: learning from Pakistan during the COVID-19 pandemic. Int J Infect Dis. 2021;113(Suppl 1):S88–90.

Islam M. Extensively drug-resistant tuberculosis in the time of COVID-19-How has the landscape changed for Pakistan? Disaster Med Public Health Prep. 2020;14(4):e9–10. pmid:32635960

Kumar P, Goyal JP. Tuberculosis during Covid-19 pandemic: challenges and opportunities. Indian Pediatr. 2020;57(11):1082. pmid:32893833

Maroof M, Pamei G, Bhatt M, Awasthi S, Bahuguna SC, Singh P. Drug adherence to anti-tubercular treatment during COVID-19 lockdown in Haldwani block of Nainital district. Indian J Community Health. 2022;34(4):535–41.

Oga-Omenka C, Tseja-Akinrin A, Boffa J, Heitkamp P, Pai M, Zarowsky C. Commentary: Lessons from the COVID-19 global health response to inform TB case finding. Healthc (Amst). 2021;9(2):100487. pmid:33607520

Soko RN, Burke RM, Feasey HRA, Sibande W, Nliwasa M, Henrion MYR, et al. Effects of coronavirus disease pandemic on tuberculosis notifications, Malawi. Emerg Infect Dis. 2021;27(7):1831–9. pmid:34152962

Uwishema O, Badri R, Onyeaka H, Okereke M, Akhtar S, Mhanna M, et al. Fighting tuberculosis in Africa: the current situation amidst the COVID-19 pandemic. Disaster Med Public Health Prep. 2022; June 8:1–3. pmid:35673793

Zimmer AJ, Klinton JS, Oga-Omenka C. Tuberculosis in times of COVID-19. J Epidemiol Community Health. 2022;76(3):310–6. pmid:34535539

Dheda K, Perumal T, Moultrie H, Perumal R, Esmail A, Scott AJ, et al. The intersecting pandemics of tuberculosis and COVID-19: population-level and patient-level impact, clinical presentation, and corrective interventions. Lancet Respir Med. 2022;10(6):603–22. pmid:35338841

Nkereuwem O, Nkereuwem E, Fiogbe A, Usoroh EE, Sillah AK, Owolabi O, et al. Exploring the perspectives of members of international tuberculosis control and research networks on the impact of COVID-19 on tuberculosis services: a cross sectional survey. BMC Health Serv Res. 2021;21(1):798. pmid:34384439

Chapman HJ, Veras-Estévez BA. Lessons learned during the COVID-19 pandemic to strengthen tb infection control: a rapid review. Glob Health Sci Pract. 2021;9(4):964–77. pmid:34933990

Anigbo AR, Gambhir L. Two years of the pandemic: Impact of COVID-19 on tuberculosis management in Nigeria. J Appl Pharm Sci. 2022;12(8):001–008.

Chen H, Zhang K. Insight into the impact of the COVID-19 epidemic on tuberculosis burden in China. Eur Respir J. 2020;56(3):2002710. pmid:32703778

Lipman M, McQuaid CF, Abubakar I, Khan M, Kranzer K, McHugh TD, et al. The impact of COVID-19 on global tuberculosis control. Indian J Med Res. 2021;153(4):404–8. pmid:34380784

Lungu PS, Kerkhoff AD, Muyoyeta M, Kasapo CC, Nyangu S, Kagujje M, et al. Interrupted time-series analysis of active case-finding for tuberculosis during the COVID-19 pandemic, Zambia. Bull World Health Organ. 2022;100(3):205–15. pmid:35261409

Hazra D, Chawla K, Shenoy VP, Pandey AK, S N. The aftermath of COVID-19 pandemic on the diagnosis of TB at a tertiary care hospital in India. J Infect Public Health. 2021;14(8):1095–8. pmid:34274858

Lakoh S, Jiba DF, Baldeh M, Adekanmbi O, Barrie U, Seisay AL, et al. Impact of COVID-19 on tuberculosis case detection and treatment outcomes in Sierra Leone. Trop Med Infect Dis. 2021;6(3):154. pmid:34449755

Lestari T, Kamaludin , Lowbridge C, Kenangalem E, Poespoprodjo JR, Graham SM, et al. Impacts of tuberculosis services strengthening and the COVID-19 pandemic on case detection and treatment outcomes in Mimika District, Papua, Indonesia: 2014–2021. PLOS Glob Public Health. 2022;2(9):e0001114. pmid:36962674

Loh FK, Thong PM, Ong CWM. The crucial need for tuberculosis translational research in the time of COVID-19. Lancet Respir Med. 2022;10(6):531–3. pmid:35338842

MacLean EL, Villa-Castillo L, Ruhwald M, Ugarte-Gil C, Pai M. Integrated testing for TB and COVID-19. Med (N Y). 2022;3(3):162–6. pmid:35169763

Malik AA, Safdar N, Chandir S, Khan U. Tuberculosis control and care in the era of COVID-19. Health Policy Plan. 2020;35(8):1130–32. pmid:32832996

Mohammed H, Oljira L, Roba KT, Yimer G, Fekadu A, Manyazewal T. Containment of COVID-19 in Ethiopia and implications for tuberculosis care and research. Infect Dis Poverty. 2020;9(1):131. pmid:32938497

Muñiz-Salazar R, Le T, Cuevas-Mota J, González-Fagoaga JE, Zapata-Garibay R, Ruiz-Tamayo PS, et al. Impact of COVID-19 on tuberculosis detection and treatment in Baja California, México. Front Public Health. 2022;10:921596.

Nalunjogi J, Mucching-Toscano S, Sibomana JP, Centis R, D’Ambrosio L, Alffenaar JW, et al. Impact of COVID-19 on diagnosis of tuberculosis, multidrug-resistant tuberculosis, and on mortality in 11 countries in Europe, Northern America, and Australia. A Global Tuberculosis Network study. Int J Infect Dis. Int J Infect Dis. 2023;130(Suppl 1):S25–9.

Narita M, Hatt G, Toren KG. Narita M, Hatt G, Toren KG. Delayed tuberculosis diagnoses during the coronavirus disease 2019 (COVID-19) pandemic in 2020—King County, Washington. Clin Infect Dis. 2021;73(Suppl 1):S74–6. pmid:33956137

Nikolayevskyy V, Holicka Y, van Soolingen D, van der Werf MJ, Ködmön C, Surkova E, et al. Impact of COVID-19 on tuberculosis case detection and treatment outcomes in Sierra Leone.Eur Respir J. 2021;57(1):154.

Santos VS, Allgayer MF, Kontogianni K, Rocha JE, Pimentel BJ, Amorim MTP, et al. Pooling of sputum samples to increase tuberculosis diagnostic capacity in Brazil during the COVID-19 pandemic. Int J Infect Dis. 2023;129:10–4. pmid:36642209

Schiza V, Kruse M, Xiao Y, Kar S, Lovejoy K, Wrighton-Smith P, et al. Impact of the COVID-19 pandemic on TB infection testing. Int J Tuberc Lung Dis. 2022;26(2):174–6. pmid:35086632

Tovar M, Aleta A, Sanz J, Moreno Y. Modelling the impact of COVID-19 on future tuberculosis burden. Commun Med (Lond). 2022;2:77.

Maurer FP, Shubladze N, Kalmambetova G, Felker I, Kuchukhidze G, Drobniewski F, et al. Impact of the COVID-19 pandemic on tuberculosis national reference laboratory services in the WHO European Region, March to November 2020. Euro Surveill. 2021;26(24):2100426. pmid:34142651

Awasthi AK, Singh PK. Tuberculosis management in India during COVID-19 crisis. J Public Health Policy. 2021;42(1):185–9. pmid:33235251

Apolisi I, Mema N, Tyeku N, Beko B, Memani B, Daniels J, et al. Supporting families with tuberculosis during COVID-19 in Khayelithsa, South Africa. Lancet Respir Med. 2022;10(6):542–3. pmid:35338838

Arega B, Negesso A, Taye B, Weldeyohhans G, Bewket B, Negussie T, et al. Impact of COVID-19 pandemic on TB prevention and care in Addis Ababa, Ethiopia: a retrospective database study. BMJ Open. 2022;12(2):e053290. pmid:35135769

Benade M, Long L, Meyer-Rath G, Miot J, Evans D, Tucker JM, et al. Reduction in initiations of drug-sensitive tuberculosis treatment in South Africa during the COVID-19 pandemic: analysis of retrospective, facility-level data. PLOS Glob Public Health. 2022;2(10):e0000559. pmid:36962535

Caren GJ, Iskandar D, Pitaloka DAE, Abdulah R, Suwantika AA. COVID-19 pandemic disruption on the management of tuberculosis treatment in Indonesia. J Multidiscip Healthc. 2022;15:175–83.

Chilot D, Woldeamanuel Y, Manyazewal T. Real-time impact of COVID-19 on clinical care and treatment of patients with tuberculosis: a multicenter cross-sectional study in Addis Ababa, Ethiopia. Ann Glob Health. 2021;87(1):109. pmid:34824990

Coutinho I, Alves LC, Werneck GL, Trajman A. The impact of the COVID-19 pandemic in tuberculosis preventive treatment in Brazil: a retrospective cohort study using secondary data. Lancet Reg Health Am. 2023;19:100444. pmid:36818594

Downloads

Published

2024-11-01

How to Cite

Shareef, S. A., Aldulaimy, M. K., & Mohammed, W. A. (2024). The Relationship between Tuberculosis and Corona Virus. Stallion Journal for Multidisciplinary Associated Research Studies, 3(5), 22–31. https://doi.org/10.55544/sjmars.3.5.4