Correlation of CA125, and Some Mineral in the Progression of Breast Cancer in Pre- and Postmenopausal Iraq Women

Abstract

Background: Breast cancer presents a severe threat to women's health worldwide, as it is the most often diagnosed cancer and the primary cause of mortality for female patients.

The aim of this study was to study the relationship between Ca 125 and insulin with some chemical tests in order to know the relationship between them and therefore the speed and accuracy in diagnosing breast cancer in women early.

Material and method: In this research, there are 160 participants (age 21 - 61 years) divided into three groups. The first group included 50 (group A) that represented Premenopausal .The second group included 55(group B) that represented postmenopausal the A and B group suffering breast cancer who visited Baghdad Medical City Hospitals-Bab Al-Moadham and the third group control group (55 participant). The blood (5ml) was drawn from every participant to separate the serum. The serum was used to measure (CA125, Insulin, C-RP, Mg, Iron and Ca).The results showed there is significantly an increase in the level of CA125 and C-RP in the serum of menopause women with breast cancer but the insulin non significantly different between study group.  In addition, there is significantly slightly increase in the level of Mg, Iron and Ca in the serum of breast cancer women than control group.

As conclusion: The relationship between Ca 125 was positive and of clinical significance for disease progression. CR-P, which developed a lot because it was a strong indicator of inflammation. As for the prognostic elements (Mg, Iron and Ca), they were of great importance in their association with the disease, and therefore it may be an important indicator in the early diagnosis of the disease. The serum levels of CA125 and CR-P were demonstrated to be of great value in the management of patients with breast cancer, and could serve as predictive indicators and for monitoring the course of disease.